Tetrazine–trans-cyclooctene ligation for the rapid construction of 18F labeled probes
نویسندگان
چکیده
منابع مشابه
Conformationally Strained trans-Cyclooctene (sTCO) Enables the Rapid Construction of (18)F-PET Probes via Tetrazine Ligation.
The bioorthogonal reaction between tetrazines and trans-cyclooctenes is a method for the rapid construction of F-18 probes for PET imaging. Described here is a second generation (18)F-labeling system based on a conformationally strained trans-cyclooctene (sTCO)-a dienophile that is approximately 2 orders of magnitude more reactive than conventional TCO dienophiles. Starting from a readily prepa...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2010
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c0cc03078c